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KMID : 1137020070180040326
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Journal of Gynecologic Oncology
2007 Volume.18 No. 4 p.326 ~ p.332
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Differential antitumor effects of sequence-dependent model in tumor cell Line: association with peroxiredoxin
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Cho Hee-Young
Lee Gyeong-Won
Kang Jung-Hun
Hah Young-Sool
Jang Joung-Soon
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Abstract
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Objective: The efficacy of two-drug combination treatment may be schedule-dependent. We investigated a simulated in-vitro interaction between taxol and doxorubicin in a Cervical cancer cell line HeLa and the role of peroxiredoxin in cytotoxicity.
Methods: Two contradicting schedules of two drugs (taxol followed by doxorubicin or vice versa) were compared each other in terms of cytotoxicity in parental HeLa cell line and the peroxiredoxin (prx)-overexpressing variant. Cytotoxic activity was determined by MTT assay. Cell cycle pertubation was evaluated by flow cytometric analysis. Protein levels were determined by western blot.
Results: The sequential treatment of taxol followed by doxorubicin (T--
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KEYWORD
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Cervix cancer, Sequence-dependent, Taxol, Doxorubicin, Peroxiredoxin
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